![]() ![]() And call them right away if you notice leg or ankle swelling. If you have heart failure, don’t take an NSAID unless your healthcare provider prescribed it for you. And worsening heart failure can cause leg and ankle swelling, too. Typically, the swelling will go away once you stop taking the medication.īut NSAIDs can also make heart failure worse. This tends to be more likely in older adults and people with kidney problems. NSAIDs commonly cause water retention, which can lead to swelling in the legs and ankles. Examples include ibuprofen (Motrin, Advil), naproxen (Aleve), and meloxicam (Mobic). Some are available over the counter (OTC), while others need a prescription. Non-steroidal anti-inflammatory drugs ( NSAIDs) can help treat pain and inflammation. They may be able to help switch you to a different diabetes medication. If you experience swelling while taking pioglitazone or rosiglitazone, talk to your healthcare provider. And as mentioned above, this has been linked to a greater risk of heart failure. Leg swelling is a well-known side effect of these medications. Pioglitazone (Actos) and rosiglitazone (Avandia) are glitazone medications that are used to treat Type 2 diabetes. Tell your healthcare provider if swelling develops so they can adjust your dose or switch you to a different medication. Glitazones are diabetes medications that can cause swelling and have also been linked to new or worsening heart failure. But it’s even more likely to happen if you’re taking pregabalin with glitazones. Leg swelling can happen if you’re taking pregabalin on its own. Taking pregabalin long term for diabetic nerve pain was associated with a greater risk of heart failure and other cardiovascular problems, possibly due to fluid retention. The same study mentioned above had similar findings with pregabalin. It’s a controlled substance, meaning there’s a risk for abuse and dependence. It’s used to treat different types of nerve pain, fibromyalgia, and seizures. Pregabalin (Lyrica) is similar to gabapentin. They may decide to lower your dose or switch you to a different medication. It’s important to tell your healthcare provider if you notice swelling while taking gabapentin. But, more research is needed to know for sure. This was the case with short-term and long-term gabapentin treatment. One retrospective study found that people taking it for this reason had a higher risk of heart failure and other cardiovascular problems, possibly due to fluid retention. Gabapentin isn’t approved for diabetic nerve pain, but it’s sometimes prescribed off-label. Swelling may be more likely if you’re older, or if you’re taking a higher gabapentin dosage. Some people taking it report fluid retention and swelling in their extremities. Gabapentin (Neurontin, Horizant, Gralise) is a medication used to treat nerve pain from shingles, seizures, and restless legs syndrome. But if it’s still an issue, they may try lowering your dose or switching you to a different medication. Your healthcare provider may suggest wearing compression socks or elevating your legs to help with swelling from amlodipine. ![]() And this may be more likely if you’re taking a higher dosage (like 10 mg daily) compared to a lower dosage. One of the most common amlodipine side effects is swelling in the legs. AmlodipineĪmlodipine (Norvasc) is a calcium channel blocker that’s prescribed for high blood pressure and chest pain. Sometimes, swelling is caused by something more serious, like a blood clot or a medical condition getting worse. But keep in mind medications aren’t the only cause. Examples include amlodipine, gabapentin, and steroids like prednisone.īelow, we’ll look at seven medications that commonly cause swelling in the legs or ankles. That’s because swelling in the legs and ankles (also called pedal edema) is a common side effect of some medications. If you notice that your shoes are tight or that you have puffy legs, you may want to check your medication list. ![]()
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